Value for Money

4.0 /10

Formula Rating

4.0 /10

Risk of Side Effects

6.5 /10


  • Potentially interesting approach to neuro-protection


  • EHT Extract is an under-studied coffee extract
  • Rest of the ingredients unimpressive
  • Only data on EHT Extract paid for by manufacturer


NERIUM EHT Review Summary

Despite seeming quite exciting at first glance, we aren’t impressed with NERIUM EHT. While the manufacturer may be right to describe it as an “age-defying nootropic” (phrasing we never like to see as it is misleading), we do not think that EHT can deliver on the many promises made by the manufacturer.

The only exciting ingredient, EHT Extract, turns out to be an under-studied coffee bean extract. The only clinical study we could find on this substance not only fails to establish firmly whether it is an objectively good nootropic, but it was funded entirely by the manufacturer. EHT is unable to bring about short-term, acute nootropic benefits, or to bring about any enhancements at all. Its effects are limited to preventing excessive damage. 

We think even those of you with more long-term goals would be better served by a stack which uses more established and better understood nootropics. 



We first came across NERIUM EHT on Amazon. While there is an official online store, we think the best prices are to be had through Amazon. 


Full NERIUM EHT Review


EHT has only recently been launched onto the market, yet it is already being discussed ferociously online. A search for “NERIUM EHT review” will return plenty of professional appraisals as well as some very good amateur user reviews.

But you can never be sure that you’re getting all the information you need. So we’ve conducted our own thorough NERIUM EHT review.

First of all, who makes EHT?




EHT seems to be the exclusive property of NERIUM. These guys are a very well established manufacturing outfit. They have a slick website and a number of niche products, including face washes, skincare products; anti-ageing products of every description.

We’re pretty skeptical about any product that describes itself as “anti-ageing”. You can’t stop ageing we’re afraid – sorry about that.

But this isn’t necessarily a case of peddling false hope. Their website is reaosnable in its claims.

NERIUM EHT is the company’s first foray into the supplement market. So what is this nootropic all about?

According to the official website, NERIUM EHT is a breakthrough in nootropic supplementation. It is apparently one of those major discoveries only just being made public by researchers:


NERIUM EHT back story


We see these kind of “visionary doctor” innovations quite often. More often than not, they turn out to be jazzed up versions of simple, run-of-the-mill extracts.

More on this later.

NERIUM EHT is described as an “age defying mind enhancement formula”.

The product derives its name from what it says is its exclusive use of the compound EHT. We are told that this mysterious EHT compound has some incredible properties:

  • Promotes stronger neuronal connections
  • Promotes optimal brain health
  • Enhances mental alertness
  • Reduce reaction times
  • Prevent memory loss

The 3 last enhancements would indeed follow on from the first 2. The official NERIUM EHT website doesn’t explicitly claim that it can prevent memory loss, but it is implied that improving neuronal connections will attenuate memory loss associated with neuron degredation.

NERIUM EHT also contains several other ingredients which, together, are said to provide the following benefits:

  • “Enhances acetylcholine effects”
  • Support for vital bodily processes
  • Keeps blood pressure normal
  • Supports “healthy sugar levels”

These are some pretty strange things to include in a natural nootropic stack.

We don’t necessarily want something to help with blood sugar regulation from our nootropics.

But it isn’t something we necessarily don’t want either.

If the ingredients used in NERIUM EHT do what the manufacturers say they can, if they give us the cognitive enhancements we’re looking for, then added health benefits would just be a bonus.

But that is IF the formula as a whole gives us what we’re looking for. So can it?

Does NERIUM EHT really work how they say it can?

What is this EHT extract? Is it really a scientific breakthrough?

Is EHT safe? What are the side effect risks?

How does it compare to other stacks on the market today in terms of cognitive enhancement and promoting brain health?

We answer all of these questions in our full NERIUM EHT review, which you can find below. If you have any questions, please let us know in the comments section at the bottom. We aim to get back to everyone within 48 hours.


NERIUM EHT is hyped by the manufacturer as a pretty impressive new nootropic. Let’s see if the formula stands up to scrutiny:




That is a pretty interesting formula.

Obviously there’s lots in here that we are already familiar with.

unfotunately, it looks like lots of ingredients have little to no nootropic value.

They may contribute to overall good health and longevity, but if you’re in the market for a nootropic, you want a nootropic.

The doses used are a little confusing too. But we will talk about that a little later too.

There are two substances in here with real nootropic potential: Huperzine A and EHT Extract.

So what is EHT Extract then?

Is it the amazing nootropic NERIUM say it is?

Unfortunately, it doesn’t look that way to us. We may be wrong (as research is limited at present), but as it stands we aren’t too optimistic.


What Is EHT Extract?

EHT is an acronym of eicosanoyl-5-hydoxytryptamide.

Given all the hype NERIUM have drummed up around EHT, you might be surprised to learn that it is a coffee bean extract.

Yes, that’s right: it’s taken from plain old coffee.

Finding concrete scientific research on this compound regarding its nootropic properties is quite difficult.

The official NERIUM EHT website keeps referencing a R&D conference document, but when we click on the link, nothing loads.


EHT Extract from coffee beans


There was, however, one study published on EHT Extract in Neurology in 2015.

The researchers in question were intrigued by the apparent reduced risk of neurodegeneration that comes with frequent coffee consumption.

The researchers hypothesized that they mind find a PP2A modulator in coffee, which might explain the neuroprotective effects associated with coffee consumption.

As they put it:

“Protein Phosphatase 2A (PP2A), the major serine/threonine phosphatase in the brain, has been implicated in neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease due to its reduced activity and methylation of its carboxy-terminal. The discovery of novel modulators of PP2A phosphatase activity from natural sources might provide a beneficial outcome in CNS therapeutics.”

As you will see in the study results, EHT was found to inhibit demethylation of PP2A in vitro.

This lead the researchers to conclude rather emphatically: “These findings indicate that EHT is one of the components responsible for the neuroprotective properties of coffee.”

That all sounds very impressive, right?

So does that mean that NERIUM EHT is able to enhance cognition through the protection of brain cells from degredation?

Not necessarily.

It may be the case that NERIUM EHT prevents neurodegeneration to a significant degree.

But that does not mean that it will have any noticable effect on your cognition today.

It does not mean that NERIUM EHT will ever have a tangible, discernible effect on your cognitive performance.

Many of the people looking at NERIUM EHT will want their cognitive functions ramped up above baseline. They do not simply want to prevent rapid decline; they want to improve function right now.

Not only that, but there is nothing to tell us that the anti-degenerative effects of NERIUM EHT are particularly pronounced relative to things like diet or green tea consumption.

The cited study (the only one we can find) just tells us that it has this action.

It doesn’t tell us how significant this is, how important PP2A is in the process of cognitive decline, or exactly how protective EHT extract is in practice.

After all, the researchers rightly say that PP2A phosphatase activity is implicated in neurodegenrative diseases, but that doesn’t mean it is a major causal factor.

Perhaps most importantly of all, this study does not show that EHT Extract is able to actually “promote strong neuronal connections.”

Nowhere in this study do we see evidence that EHT Extract can make your neurons any “stronger”, any better at communicating, or any greater in number.

To reach that conclusion, we’ll have to do an awful lot more research. But we can say for certain now that the makers of NERIUM EHT are unable to make this claim legitimately.


NERIUM EHT research bias


Finally, we noticed one major flaw with the Neurology article.

Check out the author disclaimers:


EHT Extract research disclosure


We’re not saying that being paid by the original manufacturer of an extract means that you are going to be biased. We’re saying that when the entire research team is on the payroll, we’re inclined to take the results with a pinch of salt.

This disclosure really brings out the importance of the problems highlighted above.

The reserachers imply that the neuroprotective effects of EHT Extract is pretty amazing, but it is never stated explicitly just how significant this effect is relative to other proven methods of preventing neurodegeneration.

So it seems that in reality, EHT Extract isn’t the groundbreaking new nootropic that NERIUM make it out to be.

Most people in the market for nootropics want something that will provide them with enhanced cognitive function, not merely a potential protection against decline.


Other Ingredients

The rest of the NERIUM EHT formula is hardly more encouraging.

The only actual nootropic we have here is Huperzine A.

Huperzine A does not “enhance acetylcholine effects” as NERIUM claim (it is worrying that a manufacturer is either so ill-informed or sloppy with their wording).

Huperzine A inhibits the formation of the enzyme acetylcholinesterase.

This is the enzyme responsible for the breakdown of acetylcholine (for those of you who don’t know, acetylcholine can be thought of as your focus and “learning” neurotransmitter).

Taking Hup A is therefore one way to raise acetylcholine availability in the brain.

But it isn’t the best way.

Nor is it the safest way.

Your brain needs to be able to regulate acetylcholinesterase levels. If you have too much of a build up in your brain, you will experience some fairly unpleasant side effects.

That’s why Hup A needs to be cycled regularly.

But taking prolonged breaks from EHT Extract consumption woudl surely defeat the purpose of this ingredient altogether?

Not an ideal pairing in our opinion.

-The Best Cholinergics For Boosting Focus Today-

NERIUM EHT Side Effects

We can’t give you much detail about the potential side effects of using EHT Extract.

Yes, it is a natural compound extracted from coffee.

That does intuitively make it feel safe.

But consuming small amounts of something in its natural form, along with all the fibre and other compounds which usually come with it, is a different ball game to consuming a purified extract.

We need to see a lot more clinical data on the effects of consuming EHT Extract before we are confident in saying it is safe.

The majority of the other ingredients in NERIUM EHT are relatively safe. Side effects are rare at the doses used in here (as they are quite low in some areas).

The exception here is Huperzine A.

As discussed above, you need to be careful to cycle Huperzine A properly in order to keep the risk of side effects to a minimum.

If you failt to cycle it properly, expect to experience headaches, mild confusion, irritability, anxiety, and drowsiness.

If you take Huperzine A for long, uninterrupted periods, these side effects will become more pronounced.

As always, do not take this as sound medical advice. You need to talk to a properly qualified medical professional before using NERIUM EHT, or any such supplement for that matter.

Just because NERIUM EHT was supposedly designed by a doctor does not mean that it is totally safe for everybody.

Plenty of scam supplements are “MD formulated”.

Be careful out there guys! Do your due diligence!


-Bacopa Monnieri: The Long Term Memory Booster-

NERIUM EHT Review Conclusion – Should You Buy It?

Despite the very interesting and novel formula, we are pretty unimpressed with NERIUM EHT.

It promises a great deal, but we doubt it can deliver in reality.

The main ingredient, EHT Extract, has been found in a single clinical trial to have some neuroprotective effects.

Specifically, it was found to prevent degenration of neuronal cells by reducing PP2A activity.

But we pointed out a number of caveats here.

First of all, that it has a anti-degenerative effect doesn’t mean it has an enahncing effect on your cognition from baseline.

Preventing something from collapsing does not make it any better, and that is what the majority of our readers are looking for; real improvements in focus and memory function in the short to medium-term.

NERIUM claim that EHT can “strengthen neuronal connections” – we see no evidence for this.

Secondly, we aren’t told how significant this protective effect is compared to things like exercise, or consuming certain anti-oxidants.

It may well help prevent the degeneration of neurons, but other things may do this much more effectively.

FInally, the research team in question all work for the company which produces EHT Extract.

The rest of the formula is pretty depressing.

There’s some Huperzine A, which has many problems itself, and then a bunch of ingredients that have no nootropic properties whatsoever.

All-in-all, an interesting yet ultimately disappointing nootropic supplement.

NERIUM EHT Review – “Age-Defying” Nootropic?
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